A Review of Electrophoretic Patterns in Disease*
نویسنده
چکیده
A total of 702 sera, 81 cerebrospinal fluids and 131 urine specimens were studied for the evaluation of a high resolution electrophoresis system, as well as the usefulness of electrophoresis in general. Abnormal changes were found in 41.6 percent of the serum specimens. Meaningful changes of individual fractions were most frequently encountered in the gamma frac tion. In six recognized electrophoretic patterns, more components can be identified by this system thus providing additional information for differ ential diagnosis. For instance, this system is able to demonstrate a promi nent beta-lipoprotein band in case of nephrotic syndrome, and can, there fore, distinguish this syndrome from protein-losing enteropathy. The high-resolution electrophoresis system produces good resolution for discrete gamma bands. The configuration of the monoclonal band revealed by this technique provides a preliminary identification of immunoglob u lin s, w h ich is p rac tica lly im possib le w ith the conven tional e le c trophoresis. The excellent capacity of demonstrating oligoclonal banding is one of the most distinguished features of this system. The oligoclonal bands detected in cerebral spinal fluid are very helpful for the diagnosis of dem yelinating disease and may provide a clue of the presence of tumor if detected in serum. Urine electrophoresis is a good tool for screening of Bence Jones proteinuria; false-positive results were not found and multiple monoclonal banding is specific for myelomatous disorders especially for light chain myeloma. Address reprint requests to: Dr. T. Sun, Department of Laboratories, North Shore University Hospital, 300 Community Drive, Manhasset, NY 11030.
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تاریخ انتشار 2015